serine hydrolase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T78174	Serine Hydrolase inhibitor-21		Others
	Serine Hydrolase Inhibitor-21 (compound 8), a pyridine-based serine hydrolase inhibitor, exhibits a K i of 429 nM against BuChE, and shows promise for Alzheimer's disease research [1].		Others
T15802	LY2183240		FAAH , Autophagy
	LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM).		FAAH , Autophagy
T9374	AA38-3	1-Piperidinecarboxylic acid, 4-nitrophenyl ester	FAAH , Lipase , MAGL
	AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH)		FAAH , Lipase , MAGL
T8927	WWL 154	WWL-154	FAAH
	WWL 154 is an serine hydrolase (SH) and fatty acid amide hydrolase FAAH-4 inhibitor.		FAAH
T22883	JW 480		Others
	JW480 is a potent and selective inhibitor of KIAA1363, a serine hydrolase enzyme.		Others
T23602	ABC99	ABC 99,ABC-99	Wnt/beta-catenin
	ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.		Wnt/beta-catenin
T9733	PAL-4	1H-1,2,4-Triazol-5-amine, 3-[[(4-chlorophenyl)methyl]thio]-1-[(2,3-dihydro-5-benzofuranyl)sulfonyl]-	Others
	PAL-4 stimulates the activity of LYPLAL1, a poorly characterized serine hydrolase with complex genetic links to human metabolic traits.		Others
T3990	AA26-9		Phospholipase , Serine Protease
	AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.		Phospholipase , Serine Protease
T17259	WWL113		Others
	WWL113 is a selective and orally active Ces3 and Ces1f inhibitor (IC50: 120 nM and 100 nM for Ces3 and Ces1f, respectively). WWL113 appears to display excellent selectivity for the 60-kDa serine hydrolase.		Others
T38316	ABC34
	ABC34 is an inactive control probe for JJH260 , the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). ABC34 demonstrates an IC50 value greater than ...
T64082	ABC44
	ABC44 is a potent inhibitor of serine hydrolase with IC50s of 0.1 μM and 6.5 μM for palmitoyl protein thioesterase 1 (PPT1) in situ and in vitro, respectively. ABC44 can be used to study late infantile neuron-like lipofu...
T38107	JJH260	JJH260
	JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value...
T36338	AAF-CMK (trifluoroacetate salt)
	Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 μ...
T73317	JZP-MA-13
	JZP-MA-13 is a selective α/β-hydrolase domain 6 (ABHD6) inhibitor, demonstrating impressive specificity with an IC50 value of 392 nM, and exhibits no inhibitory effects on monoacylglycerol lipase (MAGL), ABHD12, fatty ac...
T36055	Nitisinone-13C6	Nitisinone-13C6
	Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyr...

Compounds

Serine Hydrolase inhibitor-21

T78174

Target: FAAH, Autophagy

AA38-3

T9374

Synonym: 1-Piperidinecarboxylic acid, 4-nitrophenyl ester

Target: FAAH, Lipase, MAGL

Synonym: ABC 99,ABC-99

Target: Wnt/beta-catenin

PAL-4

T9733

Synonym: 1H-1,2,4-Triazol-5-amine, 3-[[(4-chlorophenyl)methyl]thio]-1-[(2,3-dihydro-5-benzofuranyl)sulfonyl]-

Target: Phospholipase, Serine Protease

AAF-CMK (trifluoroacetate salt)

Synonym: Nitisinone-13C6

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03330	BPHL Protein, Human, Recombinant (His)	Human	E. coli
	BPHL is a member of the serine protease family. BPHL is expressed large quantities in liver and kidney and in minor quantities in heart, intestine and skeletal muscle. BPHL is a specific alpha-amino acid ester hydrola...
TMPJ-00881	CTRB1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Chymotrypsinogen B (CTRB1) is a 263 amino acid protein with signal peptide (1-18) and Chymotrypsinogen B (19-263). Chymotrypsinogen B have three chains:Chymotrypsin B chain A(19-31), Chymotrypsin B chain B(34-164), Chymo...
TMPJ-00459	Esterase D Protein, Human, Recombinant (His)	Human	E. coli
	Human Esterase D is a cytoplasmic serine hydrolase that belongs to the esterase D family. Esterase D is involved in the detoxification of formaldehyde. Esterase D plays a part in a variety of substrates, including O-acet...
TMPH-02866	RBBP9 Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due ...
TMPY-03391	ESD Protein, Human, Recombinant (His)	Human	E. coli
	Esterase D, also known as ESD, is a serine hydrolase that belongs to the esterase D family. Esterase D is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of ...
TMPJ-01440	Cutinase Protein, Thermobifida fusca, Recombinant (His)	Thermobifida fusca	E. coli
	Cutinase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is cutin hydrolase. Cutinase is a serine esterase containing the classical Ser, ...